Test Name

Creatinine
Clearance

Test Code

40

Unit

mL/minute

Station

Chemistry

CPT Code

82575

Performing Facility

American Medical Labs, Herzliya
Pituah

Analyzer

Roche cobas 6000

Test Method

Kinetic Jaffe’, rate blanked, compensated, traceable to
IDMS

AML Preferred Tube

Serum and 24 h urine

Storage Instructions

See instructions for serum and urine
creatinine

Min. Volume

1 mL Serum and 10 mL of well mixed urine from measured 24
hour collection.

Comments

Creatinine clearance reference intervals
are based on a body surface area of
1.73m².

Test Includes:  Serum creatinine; urine
creatinine

Turn-Around-Time

One day

Intended Use

Renal function test; estimate glomerular filtration rate
(GFR); evaluate renal function in small or wasted subjects; follow
possible progression of renal disease; adjust dosages of medications in
which renal excretion is pivotal (e.g. aminoglycosides, methotrexate,
cisplatin)

Limitations

Exercise may cause increased creatinine clearance. The
glomerular filtration rate is substantially increased in pregnancy.
Ascorbic acid, ketone bodies (acetoacetate), hydantoin, numerous
cephalosporins and glucose may influence creatinine determinations.
Trimethoprim, cimetidine, quinine, quinidine, procainamide reduce
creatinine excretion.

Patient Preparation

Avoid cephalosporins. Have patient drink water before the
clearance is begun, and continue good hydration throughout the clearance.
If possible, drugs should be stopped beforehand.
Instruct the patient
to void at 8 AM and discard the specimen. Then collect all urine including
the final specimen voided at the end of the 24-hour collection period
(i.e. 8 AM the next morning).

The serum should be collected within 24 hours of the
start or finish of the urine collection, preferably  at the time the urine collection
is completed or when the serum is brought to the laboratory or the draw
station

Reasons for Rejection

No blood creatinine drawn or not drawn on time; improper
labeling

Adult Reference Ranges

 71-151
mL/minute