Test Name

Creatine Kinase-MB

Test Code

229

Unit

U/L

Station

Chemistry

Synonym Name/Abbreviation

CK-2; CK-MB

CPT Code

82553

Performing Facility

American Medical Labs, Herzliya
Pituah

Analyzer

Roche cobas 6000

Test Method

Immunoinhibition

AML Preferred Tube

5 mL SST gel

Storage Instructions

Refrigerated. Separate serum from cells within 45 minutes;

Stability:

8 hours at 20 to 24 ^oC

8 days at 2 to 8 ^oC

4 weeks at -20 ^oC.

Min. Volume

1 mL

Comments

The sensitivity of the test depends on the time the sample
was taken. Follow-up assays are therefore
meaningful

Turn-Around-Time

One day

Intended Use

Determination of CK-MB is an important element in diagnosis
of myocardial ischemia, as in acute myocardial infarction (AMI) or
myocarditis. It is used for confirmation and monitoring  therapy after acute myocardial
infarction. In AMI, plasma CK-MB typically rises  4 to 6 hours after the onset of
chest pains, peaks within 12 to 24 hours, and returns to baseline levels
within 24 to 48 hours. The pattern of serial CK-MB determinations is more
informative than a single
determination.

Limitations

The diagnosis of myocardial infarction should not be based
solely on MB isoenzyme, but rather should be supported by clinical
findings, ECG, and other laboratory parameters. In patients with
disposition to macro-CK formation, implausibly high CK-MB values may be
measured in relation to total CK.

 Measuring range:
3.0 to 500 U/L.

Patient Preparation

If possible, avoid muscular
exercise.

Reasons for Rejection

Citrate plasma specimen; improper
labeling

Adult Reference Ranges

7 – 25
U/L