Test
Name

Estradiol – E2

Test Code

510

Specimen

serum

Unit

pmol/L

Station

Chemistry

Synonym Name/Abbreviation

AFP

CPT Code

82670

Performing Facility

American Medical Labs, Herzliya
Pituah

Analyzer

Roche cobas 6000

Test Method

Electrochemiluminescence immunoassay (ECLIA)

AML Preferred Tube

5 mL SST gel

Storage Instructions

Refrigerated.

Stability:

12 hours 25^oC
2 days 2-8^oC
6 month -20^oC

Freeze only once.

Min. Volume

1 mL

Turn-Around-Time

One day.

Intended Use

Immunoassay for the in vitro quantitative determination of estradiol in human serum and plasma. Estrogens are produced primarily in the ovary (follicle, corpus luteum), but small quantities are also formed in the testes and in the adrenal cortex.During pregnancy, estrogens are mainly formed in the placenta. About 98 % of estradiol is bound to transport proteins (SHBG = sex hormone binding globulin). Estrogen secretion is biphasic during the menstrual cycle. The determination of estradiol is utilized clinically in the elucidation of fertility disorders in the hypothalamus‑pituitary‑gonad axis, gynecomastia, estrogen‑producing ovarian and testicular tumors and in hyperplasia of the adrenal cortex. Further clinical indications are the monitoring of fertility therapy and determining the time of ovulation within the framework of in vitro fertilization (IVF).

Limitations

Samples should not be taken from patients receiving therapy with high biotin doses (i.e. > 5 mg/day) until at least 8 hours following the last biotin administration.
For diagnostic purposes, the results should always be assessed in conjunction with the patient`s medical history, clinical examination and other findings.

18.4-11010 pmol/L

Patient Preparation

No patient preparation.

Reasons for Rejection

Improper labelling.

Adult Reference Ranges

Woman: Follicular=98.1 to 571 Ovulation=176.5 to 1153 Luteal= 122 to 1094 Postmenopausal= less than 18.4 to 183